M. Sc. University of Jabalpur (1979)

Ph. D. University of North Bengal (1984)

There are numerous useful applications of organotin compounds including biological (e.g. anti-tumour activity) and industrial (e.g. as catalysts). The emphasis of our studies in this area is synthesis and structural, and has the specific aim of delineating the factors that dictate the adoption of a particular molecular geometry in the solid state. Such a study is essential, as bibliographic surveys have revealed that in many series of the organotin compounds and indeed, significant structural diversity, as revealed by X-ray crystallography, is found despite similarities in chemical formulae. A combination of systematic crystallographic investigations in combination with 119Sn Mössbauer spectroscopy (whenever single crystal is unavailable) has proved most potent in that definitive conclusions can be made for the system under scrutiny.

The subject of the systematic research with the aim of finding relations among the structure and static and dynamic (reactivity, catalytic and biological activity) properties of a broad area of organotin(IV) chemistry of mainly new azo- , imine and azo-imine ligand skeletons including syntheses and their characterization. The research is directed to their reactions with chemically, technically, and biologically related reactants, ligand-displacement and addition reactions, reactions with a new ligand (the way and site of coordination), and to changes in the ligand newly coordinated. The focus of our research in this area is to couple biologically active moiety with organotin so as to generate active compounds against certain biological disorders. Molecular structures are studied via FT-NMR (1H, 13C, 119Sn), FT-IR, 119Sn Mössbauer, Electrospray ionization mass spectrometry (ESI-MS) and single crystal X-ray crystallography, and others. Such techniques are being used for regular characterization, on studying their molecular transformations in a molecule itself and on molecular rearrangements, regrouping of the ligands (migrations, fluxional behaviour) of organotin complexes.

Recently, we used the concept of the preassembly of suitably architectured precursors containing two or three tin centers to generate larger molecular units. A few organotin(IV) complexes have demonstrated exciting structural diversity and biological applications. Concurrently, we are investigating the cytotoxicity and anti-tumour activity of these organotin compounds with the aim to invoke biological responses in tumours using human tumour cell lines, viz., A498 (renal cancer), WIDR (colon cancer), M19 MEL (melanoma), IGROV (ovarian cancer), H226 (non-small cell lung cancer), MCF-7 and EVSA-T (breast cancer) in collaboration with Dr. Dick de Vos, Pharmachemie BV, Haarlem, The Netherlands. In addition, some selected compounds have been tested for toxicity on second larval instar of the Aedes aegypti and Anopheles stephensi mosquito larvae in order to find better larvicides and these studies being carried out in collaboration with Prof. George Eng, Department of Chemistry and Physics, University of the District of Columbia, Washington DC, USA. More recently, we are also pursuing the toxicity studies on sea urchin (Paracentrotus lividus and Sphaerechinus granularis) development in collaboration with Prof. Lorenzo Pellerito of Dipartimento di Chimica Inorganica e Analitica "Stanislao Cannizzaro" Università di Palermo, Italy.

Our group has well established collaborative link with Profs. Ray J. Butcher, Department of Chemistry, Howard University, USA; Frank E. Smith, Department of Chemistry and Biochemistry, Laurentian University, Canada; Eleonora Rivarola and Giuseppe Ruisi, Dipartimento di Chimica Inorganica e Analitica "Stanislao Cannizzaro" Università di Palermo, Italy; Antonin Ly?ka, Research Institute of Organic Synthesis, Czech Republic; Michal Hol?apek, Department of Analytical Chemistry, University of Pardubice, Czech Republic; Anthony Linden, Institute of Organic Chemistry, University of Zurich, Switzerland; Ulli Englert, Institut für Anorganische Chemie, Technische Hochschule Aachen, Germany; Rudolph Willem and Monique Biesemans, High Resolution NMR Centre (HNMR) and Department of Polymer Science and Structural Chemistry, Vrije Universiteit Brussel (VUB), Belgium, Herbert Höpfl, Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Mexico,  Hoong-Kun Fun, School of Physics, Universiti Sains Malaysia, Malaysia, E. R. T. Tiekink, Department of Chemistry, The University of Texas at San Antonio, Texas, USA, Claudio Pettinari, Dipartimento di Scienze Chimiche, Universita di Camerino, Italy

Ongoing Projects:

Department of Science and Technology (DST) sponsored research project entitled "Exploration on organotin carboxylates as a viable building block for constructing homo- and hetero- nuclear supramolecules: Synthesis, structures and biological properties"

Representative Publications (2007-08)

1. Synthesis and Characterization of Tribenzyltin(IV) and Dibenzyltin(IV) Complexes of 2-{[(2Z)-3-hydroxy-1-methyl-2-butenylidene]amino}acetic acid. Crystal Structure of Tribenzyl{2-{[(2Z)-3-hydroxy-1-methyl-2-butenylidene]amino}acetate}tin(IV), T.S. Basu Baul, C. Masharing, E. Rivarola, F.E. Smith and R.J. Butcher, Struct. Chem., 18, 231-235 (2007).

2. Synthesis and spectroscopic characterization of some triorganotin(IV) 5-[(E)-2-(4-  methylphenyl)-1-diazenyl]-2-hydroxybenzoates. Crystal and molecular structures of (Me3Sn{O2CC6H3-p-OH[N=N(C6H4-4-CH3)]})n, Et3Sn{O2CC6H3-p-OH[N=N(C6H4-4-CH3)]}OH2 and Bz3Sn{O2CC6H3-p-OH[N=N(C6H4-4-CH3)]}, T.S. Basu Baul, W. Rynjah, X. Song, G. Eng, and A. Linden,  J. Organomet. Chem., 692, 3392-3399 (2007).

3. Electrospray ionization multistage tandam mass spectrometry of complex multitin organometallic compounds, R. Jirásko, M. Hol?apek and T.S. Basu Baul, J. Mass Spectrom., 42, 918-928 (2007).

4. Di-n-octyltin(IV) complexes with 5-[(E)-2-(Aryl)-1-diazenyl]-2-hydroxybenzoic acid: Syntheses and  assessment of solid state structures by 119Sn Mössbauer and X-ray diffraction, and further insight into the solution structures using electrospray ionization MS, 119Sn NMR and variable temperature  NMR spectroscopy, T.S. Basu Baul, W. Rynjah, E. Rivarola, C. Pettinari, M. Hol?apek, R. Jirásko, U. Englert and A. Linden, J. Organomet. Chem., 692, 3625-3635 (2007).

5. Self-assembly of extended Schiff base amino acetates 2-{[(2Z)-(3-hydroxy-1-methyl-2-butenylidene)]amino}phenylpropionate and 2-{[(E)-1-(2-hydroxyaryl)alkylidene]amino- phenylpropionate skeletons incorporating organotin(IV) moiety: Synthesis, spectroscopic characterization, crystal structures, and cytotoxic activity, T.S. Basu Baul, C. Masharing, G. Ruisi, R. Jirásko, M. Hol?apek, D. de Vos and A. Linden, J. Organomet. Chem., 692, 4849-4862 (2007).

6. Methyl 2-[(E)-2-(3-formyl-4-hydroxyphenyl)diazenyl]benzoate, T.S. Basu Baul, S. Basu and E.R.T. Tiekink, Acta Crystallogr., E63, o3358 (2007).

7. Methyl 2-{[(E)-8-oxo-5,8-dihydroquinolin-5-ylidene]hydrazino}benzoate, T.S. Basu Baul, A. Mizar and E.R.T.        Tiekink, Acta Crystallogr., E63, o4256 (2007).

8. Cell proliferation inhibition and antitumour activity of novel alkyl series of diorganotin(IV) compounds, B. Koch, T.S. Basu Baul and A. Chatterjee, J. Appl. Toxicol., 28, 430-438 (2008).

9. Synthesis, characterization of some diorganotin(IV) complexes of Schiff bases derived from a non-protein amino acid. Crystal structures of {HO2CC6H4[N=C(H){C(CH3)CH(CH3)-3-OH]-p} and its di-n-butyltin(IV) complex (nBu2Sn{O2CC6H4[N=C(H){C(CH3)CH(CH3)-3-OH]-p}2), T.S. Basu Baul, C. Masharing, S. Basu, C. Pettinari, E. Rivarola, S. Chantrapromma and  Hoong-Kun Fun, Appl.  Organomet. Chem., 22, 114-121 (2008).

10. Re-visiting of 5-[(E)-2-(aryl)-1-diazenyl]-quinolin-8-ol with tweaking of Sn-Ph groups: Synthesis, spectroscopic characterization and X-ray crystallography, T.S. Basu Baul, A. Mizar, E. Rivarola and U. Englert, J. Organomet. Chem., 693, 1751-1758 (2008).

11. Anti-microbial activity of organotin(IV) compounds: a review, T.S. Basu Baul, Appl. Organomet. Chem., 22, 195-204.

12. cis- bis{5-[(E)-2-(aryl)-1-diazenyl]quinolinolato}di-n-butyltin(IV) complexes, nBu2Sn(L)2: Synthesis and characterization by IR, NMR (1H, 13C, 119Sn), 119Sn Mössbauer and Electrospray ionization MS. Crystal structures, assessment of in vitro cytotoxicity, T. S. Basu Baul, A. Mizar, A.K. Chandra, X. Song, G. Eng, R. Jirasko, M. Hol?apek, D. De Vos and A. Linden, J. Inorg. Biochem., (2008), doi:10.1016/j.jinorgbio.2008.05.001

13. 119Sn Mössbauer characterization of self assembled organotin(IV) complexes with Schiff bases containing amino acetate skeletons, S. Basu, A. Mizar, T.S. Basu Baul and E. Rivarola, Hyperfine Interactions, (2007), Accepted.

14. Amino acetate functionalized Schiff base organotin(IV) complexes as anticancer drugs: synthesis, structural characterization and in vitro cytotoxicity studies,  T.S. Basu Baul, S. Basu, D. de Vos and A. Linden, Invest New Drugs, (2008), submitted.

Total Publications: 99

1. Basu Baul, T. S. (1998): Diethyldichloro (N-(2-pyridylmethylene)-4-toluidinetin(IV): A novel diorganotin compound having anti-tumour and anti-cancer activity. Indian Patent No. : 199990, Application No. 1838/CAL/1998 dt. 16/10/98), Date of filing: 16th Oct. 1998 and Patent granted on 17th Nov. 2006.

1. Synthesis of bis (di - 2 - {(E) - (4-hydroxy-3- [(E) -(p-tolylimino) methyl] phenyl) diazenyl} benzoato) tetra- n-butyl distannoxane: An organotin(IV) compound having antitumour and anticancer activity

Miss Archana Mizar, a research scholar working for Ph. D. has been selected to carry out a part of her research work in the Department of Chemical Sciences at the University of Camerino, Italy for a year with a fellowship of EURO 15,000/- per annum under the supervision of Prof. C. Pettinari. This venture was possible because of recent bilateral agreement approved by both Rectors of the University of Camerino, Italy and North-Eastern Hill University, Shillong and active academic cooperation between Dr. T.S. Basu Baul (Supervisor) and Dr. C. Pettinari. On the basis of this and subsequent developments, Ms. Archana Mizar joined the research group of Prof. C. Pettinari, Department of Chemical Sciences at the University of Camerino, Italy on 7th Dec. '07.

Ph. D. Supervised: 07